Explain how a metabolic pathway can contain an energetically unfavorable reaction yet still occur

1)Explain how a metabolic pathway can contain an energetically unfavorable reaction yet still occur.
2)What general factors contribute to the high phosphoryl-transfer potential of ATP?
Compare ATP to acetyl CoA.
3)What is the relationship between the energy charge of a cell and control of the 4)ATP-generating pathway?
5)How is metabolism controlled?
6)What is the byproduct of cholesterol metabolism involved with digestion and what is its role?
7)What is a chylomicron?

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